Actimel überzeugt
Actimel activiert die natürlichen Abwehrkräfte – hinter dieser Aussage stehen zahlreiche wissenschaftliche Untersuchungen und Forschungsleistungen. Um die gesundheitlichen Effekte beurteilen zu können und Aussagen über die tatsächlichen Effekte zu treffen, sind wissenschaftliche Studien eine der wichtigsten Voraussetzungen. Zahlreiche Studien wurden daher gezielt mit Actimel bzw. der darin enthaltenen Kultur L. Casei Defensis durchgeführt.
Sowohl das Danone Research Center als auch unabhängige Forschungseinrichtungen hatten Actimel und L. Casei Defensis zum Untersuchungsgegenstand. Auf Grundlage dessen konnten wichtige Erkenntnisse zur Funktionsweise von Actimel gewonnen werden, die die Abwehr-aktivierende Wirkung belegen
Ausgewählte Studien zur Wirkweise:
Studien die zeigen, dass Actimel die Abwehrkräfte unterstützt:
Actimel hilft bei psychischem Stress bestimmte Parameter der natürlichen Abwehr besser aufrecht zu erhalten.
(Quelle: Marcos A, Warnberg J, Nova E, Gomez S, Alvarez A, Alvarez R, Mateos JA, Cobo JM, Eur J Nut, 2004; Vol 43: 381-389)
Eine Zusammenfassung ist hier abrufbar
Actimel kann die Aktivität bestimmter körpereigener Abwehrzellen steigern.
(Quelle: Parra MD, Martinez de Morentin BE, Cobo JM, Mateos A, Martinez JA, J Physiol Biochem, 2004; 60(2): 85-91)
Eine Zusammenfassung ist hier abrufbar
Bei täglichem Verzehr kann Actimel die Abwehrkräfte stärken und so schädlichen Einflüssen im Vorfeld begegnen.
(Quelle: CA. Pedone, CC. Arnaud, ER. Postaire, CF. Bouley and P. Reinert, Int J Clin Pract, 2000; 54(9): 568-571)
Eine Zusammenfassung ist hier abrufbar
Bei täglichem Verzehr activiert Actimel die Abwehrkräfte und kann so, besonders in der kalten Jahreszeit, helfen die natürlichen Regenerationskräfte des Körpers zu unterstützen.
(Quelle: P. Turchet, M. Laurenzano, S. Auboiron, J. M. Antoine, Journal of Nutrition, Health and Ageing, 2003; 7(2): 75-77)
Eine Zusammenfassung ist hier abrufbar
Studien, die zeigen, dass Actimel die Barrierefunktion der Darmwand stärkt.
Actimel verbessert die Funktions- und Regenerationsfähigkeit des Darmepithels.
(Quelle: K. Thoreux , D. Balas , C. Bouley , F. Senegas-Balas, Digestion, 1998; Vol 59(4): 349-359)
Eine Zusammenfassung ist hier abrufbar
Actimel verbessert die Barrierefunktion des Darmepithels.
(Quelle: Nadège Parassol, Miguel Freitas, Karine Thoreux , Guillaume Dalmasso, Raphaelle, Bourdet-Sicard, Patrick Rampal, Research in Microbiology, 2005; Vol 156(2): 256-262)Eine Zusammenfassung ist hier abrufbar
Eine Zusammenfassung ist hier abrufbar
Actimel vermindert die Anheftung unerwünschter Bakterien an das Darmepithel und so deren Eindringen in den Körper.
(Quelle: Isabelle Ingrassia, Antony Leplingard, Arlette Darfeuille-Michaud, A Applied and Environmental Microbiology, 2005; Vol 71: 2880-2887)
Eine Zusammenfassung ist hier abrufbar
Die dargestellten Studien repräsentieren nur einen Teil der wissenschaftlichen Studien, die mit Actimel und L. Casei Defensis durchgeführt wurden. Darüber hinaus liegen zahlreiche weitere Studien zur Wirkung von Actimel vor.
Aufgrund der Bestimmungen des deutschen Lebensmittelrechts ist die Danone GmbH nicht berechtigt wissenschaftliche Studien direkt an Verbraucher bzw. Nicht-Angehörige der Heilberufe herauszugeben.
Sollten Sie spezifische wissenschaftliche Fagen haben, wenden Sie sich bitte per E-Mail an: info(at)danoneteam.de
So beziehen Sie die ausführlichen wissenschaftlichen Studien:
Ausführliche Originalartikel der Studien können in öffentlichen Bibliotheken – sofern die Medien dort gelistet und archiviert sind - kostenfrei eingesehen und kopiert werden. Alternativ bietet sich eine (kostenpflichtige) Fernbestellung an.
Über die englischsprachigen Online-Datenbank des National Center of Biotechnology Infomation gelangt man auf die Seiten der Zeitschriftenhersteller. Dort können die Originalstudien (ebenfalls kostenpflichtig) bestellt werden.
Beneficial effects of Actimel on body's natural defences
After 15 years of research, this list continuously grows as more and more research institutes world wide regularly confirm or discover new beneficial effects of Actimel.
Clinical studies
Human studies that are designed to measure the efficacy of Actimel. More than 15 clinical studies done on more than 3.000 subjects supporting Actimel's effects on body’s natural defences are published in peer-reviewed scientific journals.
Published clinical studies demonstrating global beneficial effects of Actimel daily consumption on natural defences
Effects of consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 on common respiratory and gastrointestinal infections in shift workers in a randomized controlled trial
(Source: Eric Guillemard, Jérôme Tanguy, Ann’Flavigny, Stephan de la Motte, and Juergen Schrezenmeir. J. Am. Coll. Nutr. 2010 29:455-468.)Link to scientific article
Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study. Apatient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial.
(Source: Merenstein D, Murphy M, Fokar A, Hernandez RK, Park H, Nsouli H, Sanders ME , Davis BA, Niborski V, Tondu F, Shara NM.Eur J Clin Nutr. 19 Mai 2010."on-line")
Link to scientific article
Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial.
(Source: Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Br J Nutr. 2010 103 (1):56-68.)
Link to scientific article
A randomized prospective double blind controlled trial on effects of long-term consumption of fermented milk containing Lactobacillus casei in pre-school children with allergic asthma and/or rhinitis.
(Source: Giovannini M, Agostoni C, Riva E, Salvini F, Ruscitto A, Zuccotti GV, Radaelli G, Pediatr Res, 2007 Aug; 62(2): 215-20)
Link to scientific article
Use of probiotic Lactobacillus preparation to prevent diarrhoea associated with antibiotics: randomised double blind placebo controlled trial.
(Source: Hickson M, D'Souza AL, Muthu N, Rogers TR, Want S, Rajkumar C, Bulpitt CJ, BMJ, 2007 Jul 14; 335(7610): 80)
Link to scientific article
Effects of Probiotic Lactobacillus Casei DN-114 001 in Prevention of Radiation-Induced Diarrhea: Results from Multicenter, Randomized, Placebo-Controlled Nutritional Trial.
(Source: Giralt J, Regadera JP, Verges R, Romero J, de la Fuente I, Biete A, Villoria J, Cobo JM, Guarner F, Int J Radiat Oncol Biol Phys, 2008 Jul 15; 71(4): 1213-9)
Link to scientific article
Effects of a specially designed fermented milk product containing probiotic Lactobacillus casei DN-114 001 and the eradication of H. pylori in children: a prospective randomized double-blind study.
(Source: Sýkora J, Valecková K, Amlerová J, Siala K, Dedek P, Watkins S, Varvarovská J, Stozický F, Pazdiora P, Schwarz J, J Clin Gastroenterol, 2005 Sep; 39(8): 692-8)
Link to scientific article
The effect of fermented yogurt on the prevention of diarrhea in a healthy adult population.
(Source: Pereg D, Kimhi O, Tirosh A, Orr N, Kayouf R, Lishner M, Am J Infect Control, 2005 Mar; 33(2): 122-5)
Link to scientific article
Effect of fermented milk containing the probiotic Lactobacillus casei DN-114 001 on winter infections in free-living elderly subjects: a randomised, controlled pilot study.
(Source: Turchet P, Laurenzano M, Auboiron S, Antoine JM, J Nutr Health Aging, 2003; 7(2): 75-7)
Link to scientific article
Feasibility studies to control acute diarrhoea in children by feeding fermented milk preparations Actimel and Indian Dahi.
(Source: Agarwal KN, Bhasin SK, Eur J Clin Nutr, 2002 Dec; 56, Suppl 4: 56-9)
Link to scientific article
Lactobacillus casei in the control of acute diarrhea - a pilot study.
(Source: Agarwal KN, Bhasin SK, Faridi MM, Mathur M, Gupta S, Indian Pediatr, 2001 Aug; 38(8): 905-10)
Link to scientific article
Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea.
(Source: Pedone CA, Arnaud CC, Postaire ER, Bouley CF, Reinert P, Int J Clin Pract, 2000 Nov; 54(9): 568-71)
Link to scientific article
The effect of supplementation with milk fermented by Lactobacillus casei (strain DN-114 001) on acute diarrhoea in children attending day care centres.
(Source: Pedone CA, Bernabeu AO, Postaire ER, Bouley CF, Reinert P, Int J Clin Pract, 1999 Apr-May; 53(3): 179-84)
Link to scientific article
Published clinical studies supporting the effects of Actimel on immune system
A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.
(Source: Boge T, Rémigy M, Vaudaine S, Tanguy J, Bourdet-Sicard R, van der Werf S. Vaccine. 2009 Sep 18;27(41):5677-84.)
Link to scientific article
Immunomodulatory effects of the intake of fermented milk with Lactobacillus casei DN114 001 in lactating mothers and their children.
(Source: Ortiz-Andrellucchi A, Sánchez-Villegas A, Rodríguez-Gallego C, Lemes A, Molero T, Soria A, Peña-Quintana L, Santana M, Ramírez O, García J, Cabrera F, Cobo J, Serra-Majem L, Br J Nutr, 2008 Oct; 100(4): 834-45)
Link to scientific article
Effect of a probiotics supplementation on respiratory infections and immune and hormonal parameters during intense military training.
(Source: Tiollier E, Chennaoui M, Gomez-Merino D, Drogou C, Filaire E, Guezennec CY, Mil Med, 2007 Sep; 172(9): 1006-11)
Link to scientific article
Daily intake of probiotic as well as conventional yogurt has a stimulating effect on cellular immunity in young healthy women.
(Source: Meyer AL, Micksche M, Herbacek I, Elmadfa I, Ann Nutr Metab, 2006; 50(3): 282-9)
Link to scientific article
The effect of milk fermented by yogurt cultures plus Lactobacillus casei DN-114 001 on the immune response of subjects under academic examination stress.
(Source: Marcos A, Wärnberg J, Nova E, Gómez S, Alvarez A, Alvarez R, Mateos JA, Cobo JM, Eur J Nutr, 2004 Dec; 43(6): 381-9)
Link to scientific article
Daily ingestion of fermented milk containing Lactobacillus casei DN114 001 improves innate-defense capacity in healthy middle-aged people.
(Source: Parra MD, Martínez de Morentin BE, Cobo JM, Mateos A, Martínez JA, J Physiol Biochem, 2004 Jun; 60(2): 85-91)
Link to scientific article
Monocyte function in healthy middle-aged people receiving fermented milk containing Lactobacillus casei.
(Source: Parra D, De Morentin BM, Cobo JM, Mateos A, Martinez JA, J Nutr Health Aging, 2004; 8(4): 208-11)
Link to scientific article
The effect of fermented milk containing Lactobacillus casei on the immune response to exercise.
(Source: Pujol P, Huguet J, Drobnic F, Banquells M, Ruiz O, Galilea P, Segarra N, Aguilera S, Burnat A, Mateos JA, Postaire ER, BMC Inmmunol, 2008 Jun; 9-27)
Link to scientific article
New insights in the validation of systemic biomarkers for the evaluation of the immunoregulatory properties of milk fermented with yogurt culture and Lactobacillus casei (Actimel): A prospective trial.
(Source: Yoon H, Dubarry M, Bouley C, Meredith C, Portier A, Tome D, Renevot O, Blachon JL, Dugas B, Drewitt P, Postaire E, Int J Immunotherapy, 1999; 15(2): 79-89)
Link to scientific article
Published clinical studies supporting the effects of Actimel on intestinal microflora
Effect of Lactobacillus casei DN-114 001 application on the activity of fecal enzymes in children after liver transplantation.
(Source: Pawlowska J, Klewicka E, Czubkowski P, Motyl I, Jankowska I, Libudzisz Z, Teisseyre M, Gliwicz D, Cukrowska B, Transplant Proc, 2007 Dec; 39(10): 3219-21)
Link to scientific article
Milk fermented with yogurt cultures and Lactobacillus casei compared with yogurt and gelled milk: influence on intestinal microflora in healthy infants.
(Source: Gúerin-Danan C, Chabanet C, Pedone C, Popot F, Vaissade P, Bouley C, Szylit O, Andrieux C, Am J Clin Nutr, 1998 Jan; 67(1): 111-7)
Link to scientific article
Published clinical studies on the survival of the L. Casei Defensis (DN-114 001) in the digestive tract
Modulation of Lactobacillus casei in ileal and fecal samples from healthy volunteers after consumption of a fermented milk containing Lactobacillus casei DN-114 001 Rif.
(Source: Rochet V, Rigottier-Gois L, Levenez F, Cadiou J, Marteau P, Bresson JL, Goupil-Feillerat N, Doré J, Can J Microbiol, 2008 Aug; 54(8): 660-7)
Link to scientific article
Survival of Lactobacillus casei in the human digestive tract after consumption of fermented milk.
(Source: Oozeer R, Leplingard A, Mater DD, Mogenet A, Michelin R, Seksek I, Marteau P, Doré J, Bresson JL, Corthier G, Appl Environ Microbiol, 2006 Aug; 72(8): 5615-7)
Link to scientific article
Effects of orally administered Lactobacillus casei DN-114 001 on the composition or activities of the dominant faecal microbiota in healthy humans.
(Source: Rochet V, Rigottier-Gois L, Sutren M, Krementscki MN, Andrieux C, Furet JP, Tailliez P, Levenez F, Mogenet A, Bresson JL, Méance S, Cayuela C, Leplingard A, Doré J, Br J Nutr, 2006 Feb; 95(2): 421-9)
Link to scientific article
Additional scientific studies
Studies to see the effects and mechanisms of action of Actimel and L. Casei DN-114 001. Including the human studies above, effects and mechanisms of action of Actimel and L.casei DN-114 001 have been described in more than 30 scientific studies.
Scientific studies supporting the effects of Actimel on intestinal mucosa
Lactobacillus casei DN-114 001 inhibits the increase in paracellular permeability of enteropathogenic Escherichia coli-infected T84 cells.
(Source: Parassol N, Freitas M, Thoreux K, Dalmasso G, Bourdet-Sicard R, Rampal P, Res Microbiol, 2005 Mar; 156(2): 256-62)
Link to scientific article
Host-pathogens cross-talk. Indigenous bacteria and probiotics also play the game.
(Source: Freitas M, Tavan E, Cayuela C, Diop L, Sapin C, Trugnan G, Biol Cell, 2003 Nov; 95(8): 503-6)
Link to scientific article
Diet supplemented with yoghurt or milk fermented by Lactobacillus casei DN-114 001 stimulates growth and brush-border enzyme activities in mouse small intestine.
(Source: Thoreux K, Balas D, Bouley C, Senegas-Balas F, Digestion, 1998 Jul-Aug; 59(4): 349-59)
Link to scientific article
Modulation of proliferation, second messenger levels, and morphotype expression of the rat intestinal epithelial cell line IEC-6 by fermented milk.
(Source: Thoreux K, Senegas-Balas F, Bernard-Perrone F, Giannarelli S, Denariaz G, Bouley C, Balas D, J Dairy Sci, 1996 Jan; 79(1): 33-43)
Link to scientific article
Other scientific studies demonstrating the effects of Actimel
Effect of the administration of a fermented milk containing Lactobacillus casei DN-114 001 on intestinal microbiota and gut associated immune cells of nursing mice and after weaning until immune maturity.
(Source: de Moreno de LeBlanc A, Dogi CA, Galdeano CM, Carmuega E, Weill R, Perdigón G, BMC Immunol, 2008 Jun 13; 9-27)
Link to scientific article
Lactobacillus casei downregulates commensals' inflammatory signals in Crohn's disease mucosa.
(Source: Llopis M, Antolin M, Carol M, Borruel N, Casellas F, Martinez C, Espín-Basany E, Guarner F, Malagelada JR, Inflamm Bowel Dis. 2009 Feb; 15(2): 275-283)
Link to scientific article
Effect of long-term continuous consumption of fermented milk containing probiotic bacteria on mucosal immunity and the activity of peritoneal macrophages.
(Source: de Moreno de LeBlanc A, Chaves S, Carmuega E, Weill R, Antóine J, Perdigón G, Immunobiology, 2008; 213(2): 97-108)
Link to scientific article
Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells.
(Source: Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M, J Leukoc Biol, 2008 Aug; 84(2): 468-76)
Link to scientific article
Probiotic supplementation with Lactobacillus casei (Actimel) induces a Th1 response in an animal model of antiphospholipid syndrome.
(Source: Amital H, Gilburd B, Shoenfeld Y, Ann N Y Acad Sci, 2007 Sep; 1110: 661-9)
Link to scientific article
Oral administration of probiotic bacteria (E. coli Nissle , E. coli O83, Lactobacillus casei ) influences the severity of dextran sodium sulfate-induced colitis in BALB/c mice.
(Source: Kokesová A, Frolová L, Kverka M, Sokol D, Rossmann P, Bártová J, Tlaskalová- Hogenová H, Folia Microbiol (Praha), 2006; 51(5): 478-84)
Link to scientific article
Lactobacillus casei prevents the upregulation of ICAM-1 expression and leukocyte recruitment in experimental colitis.
(Source: Angulo S, Llopis M, Antolín M, Gironella M, Sans M, Malagelada JR, Piqué JM, Guarner F, Panés J, Am J Physiol Gastrointest Liver Physiol, 2006 Dec; 291(6): 1155-62)
Link to scientific article
Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn's disease.
(Source: Carol M, Borruel N, Antolin M, Llopis M, Casellas F, Guarner F, Malagelada JR, J Leukoc Biol, 2006 May; 79(5): 917-22)
Link to scientific article
Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells.
(Source: Tien MT, Girardin SE, Regnault B, Le Bourhis L, Dillies MA, Coppée JY, Bourdet-Sicard R, Sanonetti PJ, Pédron T, J Immunol, 2006 Jan 15; 176(2): 1228-37)
Link to scientific article
pH-, Lactic acid-, and non-lactic acid-dependent activities of probiotic Lactobacilli against Salmonella enterica Serovar Typhimurium.
(Source: Fayol-Messaoudi D, Berger CN, Coconnier-Polter MH, Liévin-Le Moal V, Servin AL, Appl Environ Microbiol, 2005 Oct; 71(10): 6008-13)
Link to scientific article
Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid.
(Source: Llopis M, Antolín M, Guarner F, Salas A, Malagelada JR, Gut, 2005 Jul; 54(7): 955-9)
Link to scientific article
Lactobacillus casei DN-114 001 inhibits the ability of adherent-invasive Escherichia coli isolated from Crohn's disease patients to adhere to and to invade intestinal epithelial cells.
(Source: Ingrassia I, Leplingard A, Darfeuille-Michaud A, Appl Environ Microbiol, 2005 Jun; 71(6): 2880-7)
Link to scientific article
Effect of fermented milk containing probiotic bacteria in the prevention of an enteroinvasive Escherichia coli infection in mice.
(Source: Medici M, Vinderola CG, Weill R, Perdigón G, J Dairy Res, 2005 May; 72(2): 243-9)
Link to scientific article
Differential activities of four Lactobacillus casei promoters during bacterial transit through the gastrointestinal tracts of human- microbiota-associated mice.
(Source: Oozeer R, Furet JP, Goupil-Feuillerat N, Anba J, Mengaud J, Corthier G, Appl Environ Microbiol, 2005 Mar; 71(3): 1356-63)
Link to scientific article
Initiation of protein synthesis by a labeled derivative of the Lactobacillus casei DN-114 001 strain during transit from the stomach to the cecum in mice harboring human microbiota.
(Source: Oozeer R, Mater DD, Goupil-Feuillerat N, Corthier G, Appl Environ Microbiol, 2004 Dec; 70(12): 6992-7)
Link to scientific article
Lactobacillus casei reduces CD8+ T cell-mediated skin inflammation.
(Source: Chapat L, Chemin K, Dubois B, Bourdet-Sicard R, Kaiserlian D, Eur J Immunol, 2004 Sep; 34(9): 2520-8)
Link to scientific article
Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa.
(Source: Borruel N, Casellas F, Antolín M, Llopis M, Carol M, Espíin E, Naval J, Guarner F, Malagelada JR, Am J Gastroenterol, 2003 Apr; 98(4): 865-70)
Link to scientific article
Increased mucosal tumour necrosis factor alpha production in Crohn's disease can be downregulated ex vivo by probiotic bacteria.
(Source: Borruel N, Carol M, Casellas F, Antolín M, de Lara F, Espín E, Naval J, Guarner F, Malagelada JR, Gut, 2002 Nov; 51(5): 659-64)
Link to scientific article
Lactobacillus casei is able to survive and initiate protein synthesis during its transit in the digestive tract of human flora-associated mice.
(Source: Oozeer R, Goupil-Feuillerat N, Alpert CA, van de Guchte M, Anba J, Mengaud J, Corthier G, Appl Environ Microbiol, 2002 Jul; 68(7): 3570-4)
Link to scientific article
Food supplementation with milk fermented by Lactobacillus casei DN-114 001 protects suckling rats from rotavirus-associated diarrhea.
(Source: Guérin-Danan C, Meslin JC, Chambard A, Charpilienne A, Relano P, Bouley C, Cohen J, Andrieux C, J Nutr, 2001 Jan; 131(1): 111-7)
Link to scientific article
The association of yogurt starters with Lactobacillus casei DN-114 001 in fermented milk alters the composition and metabolism of intestinal microflora in germ-free rats and in human flora-associated rats.
(Source: Djouzi Z, Andrieux C, Degivry MC, Bouley C, Szylit O, J Nutr, 1997 Nov; 127(11): 2260-6)
Link to scientific article
Die dargestellten Studien repräsentieren nur einen Teil der wissenschaftlichen Studien, die mit Actimel und L. Casei Defensis durchgeführt wurden. Darüber hinaus liegen zahlreiche weitere Studien zur Wirkung von Actimel vor.
Aufgrund der Bestimmungen des deutschen Lebensmittelrechts ist die Danone GmbH nicht berechtigt wissenschaftliche Studien direkt an Verbraucher bzw. Nicht-Angehörige der Heilberufe herauszugeben.
Sollten Sie spezifische wissenschaftliche Fagen haben, wenden Sie sich bitte per E-Mail an: info(at)danoneteam.de
So beziehen Sie die ausführlichen wissenschaftlichen Studien:
Ausführliche Originalartikel der Studien können in öffentlichen Bibliotheken – sofern die Medien dort gelistet und archiviert sind - kostenfrei eingesehen und kopiert werden. Alternativ bietet sich eine (kostenpflichtige) Fernbestellung an.
Über die englischsprachigen Online-Datenbank des National Center of Biotechnology Infomation gelangt man auf die Seiten der Zeitschriftenhersteller. Dort können die Originalstudien (ebenfalls kostenpflichtig) bestellt werden.